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Research

The Department of Critical Care Medicine at Queen’s University conducts a wide range of clinical research, both peer reviewed academic studies and industry sponsored clinical trials. The research group is highly collaborative with the Canadian Critical Care Trials Group (CCCTG).

Research Director: Dr. John Muscedere

Research Coordinators: Miranda Hunt & Tracy Boyd

Researchers of the Department of Critical Care Medicine, their profiles and selected publications:

Dr. John Muscedere is the Research Director of the Critical Care Program at Kingston Health Sciences Centre. John is an accomplished critical care researcher whose primary research interests include nosocomial infections such as ventilator associated pneumonia (VAP), clinical practice guidelines, knowledge translation, and patient outcomes following critical illness. John has been involved in the development of best practice based guidelines, including for the prevention, diagnosis and treatment of VAP, therapeutic hypothermia following cardiac arrest, and sepsis. He is also the Scientific Director for the Canadian Frailty Network (CFN), which is a national network dedicated to improving the care of frail, elderly patients with life limiting illnesses.

Muscedere, J., Maslove, D. M., Boyd, J. G., O’Callaghan, N., Sibley, S., Reynolds, S., ... & Jones, G. (2018). Prevention of Nosocomial Infections in Critically Ill Patients With Lactoferrin: A Randomized, Double-Blind, Placebo-Controlled Study. Critical care medicine.

Muscedere J, Waters B, Aditya Varambally, Sean M. Bagshaw, J. Gordon Boyd, David Maslove MD, Stephanie Sibley, Kenneth Rockwood. The Impact of Frailty on Intensive Care Unit Outcomes: A Systematic Review and Meta-Analysis. Intensive Care Medicine, 2017 Aug;43(8):1105-1122. doi: 10.1007/s00134-017-4867-0. Epub 2017 Jul 4.

 

Muscedere John, Kim Perry, Aitken Peter, Gaucher Michael, Osborn Robin, Farrell Barbara, Holroyd-Leduc Jayna, Mallery Laurie, Siu Henry, Downar James, Lee Todd C., McDonald Emily, Burry Lisa. Proceedings of the Canadian Frailty Network Summit: Medication Optimization for Frail Older Canadians, Toronto, Monday April 24, 2017. Canadian Geriatrics Journal, 2017; 20(4): 253-263.

 

Waters B, Muscedere J. A 2015 Update on Ventilator-Associated Pneumonia: New Insights on its Prevention, Diagnosis, and Treatment. Current Infectious Disease Reports, 2015; 17 (8):41. DOI 10.1007/s11908-015-0496-3, PMID: 26115700

 

John Muscedere. Which Antibiotic for Hospital Acquired Pneumonia Caused by MRSA. British Medical Journal. BMJ 2014; 348: g1469. doi: http://dx.doi.org/10.1136/bmj.g1469 (Published 13 February 2014).

 

J. Muscedere, T. Sinuff, D.K. Heyland, P. M. Dodek, S. P. Keenan, G. Wood MD, X. Jiang, A.G. Day, D. Laporta, M. Klompas for the Canadian Critical Care Trials Group. The Clinical Impact and Preventability of Ventilator-Associated Conditions in Critically Ill Mechanically Ventilated Patients. Chest, 2013;144(5):1453-60. doi: 10.1378/chest.13-0853.

 

Dr. J. Gordon Boyd – Dr. Boyd is Clinician Scientist at Kingston Health Sciences Centre, practicing both neurology and intensive care medicine.  His main research interests focus on the acute and long-term neurological consequences of critical illness, including translational research using proteomic approaches to identify novel serum biomarkers. His clinical research program uses non-invasive techniques such as Near Infrared Spectroscopy (NIRS), to monitor brain function in critically ill patients.  

Semrau, J. S., Scott, S. H., Hamilton, A. G., Petsikas, D., Payne, D. M., Bisleri, G., ... & Boyd, J. G. (2018). The relationship between cerebral oxygen saturation and quantitative metrics of neurological function after coronary bypass surgery; a feasibility study. The Journal of cardiovascular surgery.

Wood MD, Maslove DM, Muscedere JG, Day AG, Boyd, JG. (2017) Low brain tissue oxygenation contributes to the development of delirium in critically ill patients: A prospective observational study. J Crit Care.;41:289-295. doi: 10.1016/j.jcrc.2017.06.009.

Park A, Chapman M, McCredie CA, Debicki D, Gofton, T, Norton, L., Boyd, JG (2016).  EEG utilization in Canadian intensive care units: A multicentre prospective observational study.   Seizure 43, 42-47.

 

Wood, MD., Maslove D., Muscedere J., Scott SH., Day A, Boyd, JG (2016).  Assessing the relationship between brain tissue oxygenation and neurological dysfunction in critically ill patients: study protocol.  Int. J. Clin. Trials, 3(3) 98-105. 

 

Boyd, JG., Smithson LJ, Howes D, Muscedere, J., Kawaja MD (2016).  Serum proteomics as a strategy to identify novel biomarkers of neurologic recovery after cardiac arrest: a feasibility study.  Intensive Care Medicine-Experimental (epub May 2016). 

 

Wood, M., Song, A., Maslove D., Ferri C., Howes, D., Muscedere J., Boyd, J.G. (2015).  Brain tissue oxygenation in patients with septic shock: a feasibility study Can. J. Neuro. Sci. 43 65-73.



Dr. David Maslove – Dr. Maslove is a Clinician Scientist specializing in Internal medicine and Critical Care Medicine at Kingston Health Sciences Centre. Dr. Maslove’s research is focused on precision critical care. His research aims include the development novel datasets with the capacity to merge biomedical data types, as well as the analytic tools needed to translate raw data into medical knowledge. David also develops methods to collect and validate clinical data from electronic medical records, as well as waveform data from bedside monitors, and to combine these using novel data structures. For more information about Dr. Maslove’s research, please visit http://www.conduitlab.org

Maslove DM, Levin Y. What the business school can teach the medical school about precision, and vice versa. J Crit Care 2018 May 10. p.S0883-9441(18)30543-4

 

Kroll RR, McKenzie ED, Boyd JG, Sheth P, Howes D, Wood M, Maslove DM. Use of wearables for post-discharge monitoring of ICU patients: A feasibility study. J Intensive Care. 2017 5(26).

 

Maslove DM, Lamontagne F, Marshall JC, Heyland DK. A path to precision in the ICU. Crit Care. 2017 Apr 3;21(1):79. PMID: 28366166.

 

Maslove DM, Dubin JA, Shrivats A, Lee J. Errors, Omissions, and Outliers in Hourly Vital Signs Measurements in Intensive Care. Crit Care Med. 2016 Nov;44(11):e1021-e1030. PMID: 27509387.

 

Maslove DM, Marshall JC. Diagnostic utility of different blood components in gene expression analysis of septic shock. Shock. 2016 Mar;45(3):292-8. PMID: 26618988.

 

Lee J, Maslove DM. Using information theory to identify redundancy in common laboratory tests in the intensive care unit. BMC Med Inform Decis Mak. 2015 Jul;15:59. PMID: 26227625.

Maslove DM, Wong HR. Gene expression profiling in sepsis: timing, tissue, and translational considerations. Trends Mol Med. 2014 Apr;20(4):204-13. PMID24548661.